 If you liked
ef: A Tale of Memories.
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 ...then you might like
Ookami to Koushinryou
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This is a somewhat weird recommendation since Spice & Wolf is rather lighthearted and funny though it does touch on more serious elements. While ef: Tale of Memories is more serious and melancholical. However they both feature some amount of romance (ef - alot, S&W - teasing which develops later) the reason I thought of this recommendation is that the relationship between Miyako and Hiro is the same sort of teasing relationship Lawrence and Holo have. The thing is that S&W is a pretty long light novel series so it develops slower than EF which is really short. Both series are very good though so
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