Slime Taoshite 300-nen, Shiranai Uchi ni Level Max ni Nattemashita

Both anime are isekai series with an OP female protagonist who is reincarnated, develops an unusual family structure, and spends most of their time living life at their own pace. Slime Taoshite is firmly into comedic SOL, while Leadale includes a mystery element as the protagonist wonders how she and others ended up in this world. 

This anime reminds me of Kobayashi. The vibe is similar. The way those girls fond the main character, which is also a girl, is similar to Kobayashi, which eventually living under the MC care. Plus, Kobayashi and Azusa, both have kinda like, a man-ly type of character, a cool character, which adding to the vibe. Oh, lastly, both anime have this magical touch in them, which is in my preference.  

Comedic isekai slice of life with an airhead protagonist that focus on how they slowly grow their family/guild. 

Isekai slice of life series, both with plots caused by interacting with slimes in different ways. 

Both MCs are witches and have a peaceful story with a little shoujo-ai teasing. 

Both are chill laid back and wholesome isekai shows with a cute and over powered female protagonist that just want to have a quiet life 

Slime? Yes An anime about slimes "TenSura" is about a literal slime, while "Slime 300" is about fighting slimes. Nevertheless, both series focus on how a person can be so powerful through the influence of slimes. 

Crew energy and characters races plus motivation seems extremely attached to the main characters journey, despite their own objectives. Although Azusa may be more eccentric than Rein they seem to have pretty laid back personalities nonetheless. If you like shows with a good balance in action (surprisingly), slice of life, fantasy/adventure (party RPG style) and a great dynamic between the characters these shows are good picks between each other for sure. 

Both series focus on a female protagonist who has been isekai'd and realizes she has OP abilities, although Slime has a more chaotic and comedic sensibility compared to Saint's focus on drama and romance. 

Taking place in luscious landscapes with vibrant soundtracks, both Yuru Camp and Slime Taoshite take the comfy road in their comedy and character dynamics, even if Yuru Camp tends to be a bit more relaxed in its atmosphere. 

Both are laidback comedies and the main character's a witch that adopted some child and became a step mother. Except the other one has a isekai incarnation and the other one doesn't. 300Slimes has more characters living with the witch and adventuring, the other one is more normal family mothering. Personally I think that theese 2 belong in the same subgenre of comfy anime. 

One of the things which frustrates me about quite a few isekai series is a lack of realism in that many times the heroes simply have things handed to them without having to work for them because they are just so amazing, right? Well, in both of these cases the main character of the isekai does in fact have to work for their day to day needs and while in Azusa's case the narrative skips the hard work, she still works hard, and with Kazuma - well, he finds himself with the worst luck ever. So, for those looking for a change-up that the other offers from your typical isekai, check the other out. read more 

Both shows are isekais featuring a girl who lived a pressure-filled life previously, and got reincarnated into a fantasy world after meeting an early death hoping to live normal and relaxing lives. But they get interrupted as both MCs happen to be way too overpowered for their liking and as such, they draw unwanted attention to themselves. 

-Both are positivity oriented anime. Whatever negative happens, you will always know that everything is going to be alright -Both have some level of cuteness, although 300 Year Slime anime is much cuter at the level of CGDCT theme -Both have OP main characters 

Cute girls going cute things but make it wholesome found family Isekai! 

Both are wholesome, relaxed reincarnation shows. The general mood is positive, and some troubles happen just to have more positivity later. Both shows have OP MCs. They are those satisfying, "can-beat-everything" characters. So if you're also satisfied with such MCs, these two have them. Both shows have MCs with cuuuute 😍 companions. They are generally female, unless we meet some male ones in the Reborn Demon Lord. 300 Years Slime does not have romance, but it's a very relaxed slice of life with wholesomeness. Actions are not very intense, and you feel that everything will be fine in a few minutes, even in the most troublesome scenes. In comparison, Reborn Demon Lord is also a harem romance, and has a bit more intense action. But you can still anticipate the positivity after every trouble. I admit, these may be a bit like kids shows in that aspect, but it's only as much important as you care. These are not plot oriented shows, so plot doesn't need to be strong like a mystery show. If you expect a flawless plot, these are definitely NOT FOR YOU. You may think these plots are like strainers because of so many possible plotholes that may be there. I don't even know how much, since I just ignored almost all of them. In general, I think both shows are for those who don't care too much about a strong plot, and just want to enjoy a relaxed show; even if the plot is not very strong. read more 

-Coffee shops with the appeal of being insulted in a sadistic manner -Fanservice dump character -Moe but in Blend-S it's good -Very old short people 

This anime is recommend just to Isekai fans This anime is very Similar to i've been killing slime for 300 years but a bit Underatted and A character Slime is More of them in This anime Yuji Not Hunter slime but Yuji like to Hunter Monster and in addiction Yuji not Monster hunter but he is Tamer not like MC others isekai anime in Tensei kenja no isekai life No Comedy In 23 Minutes just Adventure,Action already in 23 Minutes but in I've been killing slime for 300 years all episode Contain Comedy and Adventure more them and do you know Yuji is MC OP and very Underatted and the strongest but not much MC OP : 8/10 Strongest : 9/10 Rate : 7/10 read more 

Cute girls fighting "monsters" in a fantasy world, very comforting and a good break from very violent action packed anime.  

Both are light-hearted slice of life anime. Nothing too serious, so you can enjoy exciting activities and wonderful feelings the entire time. 

Slime Taoshite 300-nen, Shiranai Uchi ni Level Max ni Nattemashita I've Been Killing Slimes for 300 Years and Maxed Out My Level Is very similar to this show. Similarities: Powerful people wanting peaceful lives. Homely feeling and helping people around Protecting people trying not to be OP Stories are very different though but the protagonists can be similar  

Both are isekais with OP MCs and they're surrounded by girls of different races and breeds. 

the story of the 2 anime are completely different,but they have the same slow life vibes 

one is an isekai, one is a magic girl slice of life, but they have similar sense of humor. the world buildings are Kafkaesque surreal, many cool-looking magic practices turned out to be mundane bureaucracy red tapes. 

Both animes have MCs that where overworked or mistreats and died. After there pasting they meet with a god and sent into another world to have a new layback life with a unique skill or power. Both have the MC slowly grow their family/guild. Both MC wanting a peaceful new life but end up creating a family with the worlds most powerful beings.  

Both series are isekai anime that take their own spins on the ideas, emphasizing a wide range of characters and creature, a homespun aesthetic, and a familial atmosphere for their casts of characters. 

Both isekai series feature OP female protagonists who use their powers to try to create comfortable lives for themselves in different ways, even as their increasing connections find themselves involved in more complex situations (although Mitsuha leans into the chaos moreso than Azusa). 

Despite their drastic differences in genre and tone, both series take place in beautiful rural environments and focus on a charismatic female character who creates a strong friend group (with Sapphic subtext) with the other characters through her skills and willingness to reach out to others. 

In both the FL got reincarnated into an Isekai after dying and maxed to level 99! the shows aren't really similar though. 

I didn't see these two shows being compared to one another so I guess I'll do it... These shows are almost identical in some ways, both are Isekai where the protagonist is somewhat non-confrontative with the outside world because of circumstances in their old world, in slime 300 that is because the protag overworked in her previous life and doesn't want to think about putting too much pressure on her and her peers while in lvl 2 the protag is against attacking any race just because of that race. Both are also incredibly powerful and arguably the most powerful beings in their worlds and as a result a lot of trouble comes their way anyway, for slime 300 that is through various reasons among which people trying to test their strength against her and her house mates running into political trouble while in lvl 2 different sides of the human-demon conflict going on the show keep trying to draft him. In the end though, their chill/calm lives are allowed to happen in a silent town away from conflict and they both gather groups of friends due to the circumstances of the show (often through previous combat). Interestingly enough, they both become overpowered after killing slime. Differences are: lvl 2 takes place on the backdrop of a demon/human war which is often an important plot point, lvl 2 has actual romance in it while slime 300 mainly has a lot of yuri baiting and finally, slime 300 seems to lack a permanent antagonist while lvl 2 has somewhat of a hostile team rocket like character that tries (and fails) to ruin the protagonist's life.  read more 

Similarities - Both MCs are female and voiced by the same person - Both MCs are reincarnated/isekai from modern world to fantasy - Both MCs are outcasts/socially disconnected - Both MCs have an unfair levelling advantage - Both MCs aren't seen as human (spider/witch) - Both MCs befriend different species (dragon/elves) - Both MCs use their powers to heal/help humans Differences - Kumo Desu is a class that gets reincarnated VS slime 300 is a single female MC that gets isekai - Kumo Desu has an underlying plot VS slime 300 is adventure/comedy and level grinding  

The main character trains his/her whole life to be the most powerful being ever, succeeds, and also becoming friends with a fangirl sidekick who wants to be as powerful as him/her. Both hilarious with the main difference of not being in the same kind of world. 

Featuring witches as their protagonists, both series emphasize the slow life aspects and surrounding families of their characters, even though Flying Witch's iyashikei and Slime Taoshite's OP reincarnation isekai provide contrasting tones. 

Finding an "isekai" anime is easy; however, finding an "isekai" anime with a female protagonist that mainly focuses on wholesome and comedic aspects is difficult. But don't worry because I got you covered. Here's some series that primarily focuses on just that. I'm sure you'll find the other as equally enjoyable if you find either of these entertaining.